iS CLINICAL Youth Intensive Crème Review

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Quick Verdict

Best for: normal to dry, mature, or dehydrated skin that wants plush moisture plus visible smoothing.
Skip if: you’re very oily or prefer lightweight gel creams year-round.
Bottom line: a results-driven, antioxidant- and peptide-focused cream with a luxe feel and noticeable improvements with consistent use.

Formula & Key Ingredients

This crème uses a well-rounded approach to common signs of aging:

• Hyaluronic acid (multiple molecular weights): helps draw moisture to the skin for a plumper, more cushioned look.
• Peptides (including copper peptide derivatives): help support the look of firmer, more resilient skin over time.
• Antioxidants (vitamin C derivatives, vitamin E, SOD): help defend against environmental stressors that can contribute to dullness and uneven texture.
• Botanical extracts: provide soothing support to help keep the moisture barrier comfortable.

Note: Youth Intensive Crème is peptide- and antioxidant-led. It’s not built around high-strength retinoids, which is one reason many sensitive-leaning users find it easier to tolerate than traditional retinol night creams.

Texture & Application

The texture is rich, cushiony, and non-greasy. It melts in and leaves a satin finish rather than a heavy, waxy film.

• Night: apply a pea- to almond-size amount over serums as your final step.
• Day (dry/mature skin): press a small amount onto cheeks and around the perimeter of the face under SPF for comfort without feeling heavy.
• Layering tip: if you use stronger acids or retinoids, alternate nights or apply this crème on top to help buffer potential dryness.

Results & Performance

What many people notice with consistent use:

• Immediately: skin feels softer, looks more supple, and makeup can sit more smoothly.
• Weeks 3–4: fine lines may look softened; tone can appear more even and rested.
• Weeks 6–8: skin can look firmer and bouncier, with fewer dry or rough patches.

The finish looks polished (not shiny), which makes it a strong daytime option in cool or dry climates and an excellent sealing step at night year-round.

Who It Is For vs Who Should Skip

Choose it if your skin runs dry, your cheeks feel tight by midday, or you want firming support without jumping straight to high-strength retinoids.
Skip it if you’re very oily or live in a humid climate and dislike any feel of richness. In that case, consider a lighter moisturizer for daytime and reserve Youth Intensive Crème for nights or drier areas.

Value for Money

This is a premium-priced cream. It makes the most sense if you want one step that delivers deep comfort plus visible smoothing, and you’ll use it consistently. If you prefer lightweight textures or your skin is oily, you may get better value from a lighter moisturizer paired with a separate peptide serum.

Pros ✅

• Deeply hydrating with a cushiony, non-greasy finish
• Supports a firmer-looking complexion with peptides and antioxidants
• Layers well over serums and under SPF (especially for dry/mature skin)

Cons ❌

• Premium price point
• Rich texture may feel heavy for very oily skin
• Visible changes take consistent use over several weeks

How To Use (Step-by-Step)

1. Cleanse and gently pat dry.
2. Serum: vitamin C in the morning, or your preferred hydrating/repair serum at night.
3. Crème: press Youth Intensive Crème over face and neck.
4. Daytime: finish with broad-spectrum sunscreen.
5. Weekly rhythm: if you use retinoids, alternate nights or buffer by applying this crème over your retinoid.

Comparison Table

Product Name	Key Benefit	Skin Type Suitability	Anti-Aging Focus
iS CLINICAL Youth Intensive Crème	Deep hydration, helps soften fine lines, supports elasticity	Normal, dry, mature	Peptides + antioxidants for visible smoothing and resilience
La Mer Crème de la Mer	Rich hydration and barrier support	Dry, very dry	Moisture support with Miracle Broth™
SkinCeuticals Triple Lipid Restore 2:4:2	Helps replenish barrier lipids and improve comfort	Normal, dry, mature	Anti-aging support through lipid replenishment
Estée Lauder Revitalizing Supreme+ Night Crème	Overnight hydration and smoother-looking skin	Normal to combination	Firming and moisture-focused night care

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Final Thoughts

iS CLINICAL Youth Intensive Crème is a smart pick if you want a richer moisturizer that feels luxurious and supports smoother, firmer-looking skin over time. It’s especially appealing for dry, dehydrated, or mature skin—either as a nightly “seal it in” step or as daytime comfort in drier climates.

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See also

If you’re comparing rich, anti-aging moisturizers, see how Augustinus Bader The Rich Cream stacks up, and consider Neocutis Bio Cream Firm Riche as another intensive firming option. – For a serum-first routine that targets multiple signs of aging, read our Clarins Double Serum review. – Explore a more classic luxury texture in our Tatcha Ageless Enriching Renewal Cream review. – If you like pairing your moisturizer with a growth-factor treatment, see our SkinMedica TNS Recovery Complex review.

Frequently Asked Questions ▾

1) How is Youth Intensive Crème different from a basic moisturizer?
It pairs peptides and antioxidants with multi-weight hyaluronic acid to support hydration, firmness, and radiance—not just moisture.

2) Can sensitive skin use it?
Many people can, since it isn’t a high-strength retinoid formula. Still, patch test first and introduce it slowly if your skin is reactive—especially if you use acids or retinoids in the same routine.

3) When should I apply it?
Use it at night as your last step over serums. If your skin is dry or mature, you can also apply a thin layer in the morning under SPF for added comfort.

4) Will it clog pores?
It’s a richer cream, so results vary. If you’re oily or breakout-prone, try it at night only or limit it to drier areas (like cheeks) and use a lighter moisturizer on the T-zone.

5) Can I layer it with retinoids or vitamin C?
Yes. Use vitamin C in the morning and apply this crème over hydrating serums as needed. With retinoids at night, either apply this on top to buffer or alternate nights to reduce dryness.